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Search Results for " Raf kinases "

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カタログ番号	製品名	別名	ターゲット
T3711	RAF709		Raf
	RAF709 is a novel Raf kinase inhibitor with IC50s of 0.5 and 1.8 nM for c-Raf and b-Raf, respectively.		Raf
T10599	BRAF inhibitor		Raf
	BRAF inhibitor is an inhibitor of B-Raf.		Raf
T1845	B-Raf IN 1		Raf
	B-Raf IN 1 is a B-Raf (IC50: 24 nM) and c-Raf (IC50: 25 nM) inhibitor.		Raf
T2074	Raf inhibitor 1	B-Raf inhibitor 1	Raf
	B-Raf inhibitor 1 (B-Raf inhibitor 1) is a potent and selective B-Raf inhibitor.		Raf
T4167	Raf inhibitor 1 dihydrochloride	B-Raf inhibitor 1 dihydrochloride	Raf
	Raf inhibitor 1 dihydrochloride (B-Raf inhibitor 1 dihydrochloride) is a potent and selective B-Raf inhibitor.		Raf
T2295	SB-590885		Raf
	SB590885 is an effective B-Raf inhibitor (Ki: 0.16 nM, in a cell-free assay). The selectivity of SB590885 for B-Raf is 11-fold greater over c-Raf, no acts to other human kinases.		Raf
TQ0048	BI-882370		Raf
	BI-882370 is a specific RAF kinase inhibitor. BI-882370 inhibits the oncogenic BRAFV600E-mutant, the WT BRAF and CRAF kinases (IC50s: 0.4, 0.8 and 0.6 nM). BI-882370 also inhibits SRC family kinases.		Raf
T15794	LUT014		Raf
	LUT014 is a B-Raf inhibitor (IC50: 11.7 nM) and developed to decrease dose-limiting acneiform lesions associated with EGFR Inhibitors treatment.		Raf
T4133	CCT196969		Raf , Src
	CCT196969 is a novel orally available, pan-RAF inhibitor with anti-SRC activity. It also inhibits SRC, LCK, and the p38 MAPKs.		Raf , Src
T4194	Raf inhibitor 2	CID-25014542,CID 25014542,CID25014542	Raf
	Raf inhibitor 2 (CID 25014542) is novel inhibitor of Raf kinases.		Raf
T2473	PLX-4720	PLX4720	Raf
	PLX-4720 is a potent and selective inhibitor of B-Raf (V600E) (IC50: 13 nM), equally potent to c-Raf-1(Y340D and Y341D mutations).		Raf
T5172	AZ304		c-Fms , Raf , p38 MAPK , Autophagy
	AZ304 is an ATP-competitive dual BRAF kinase inhibitor, potently inhibits BRAF (WT), BRAF (V600E), and wild type CRAF (IC50s: 79/38/68 nM).		c-Fms , Raf , p38 MAPK , Autophagy
T6318	AZ 628		Apoptosis , Raf
	AZ628 is a new pan-Raf inhibitor for BRAF, BRAFV600E, and c-Raf-1 with IC50 of 105 nM, 34 nM and 29 nM, also inhibits VEGFR2, DDR2, Lyn, Flt1, FMS, etc.		Apoptosis , Raf
T6296	RAF265	CHIR-265	Apoptosis , Raf , VEGFR , Autophagy
	RAF265 (CHIR-265) (CHIR-265) is a potent selective inhibitor of C-Raf/B-Raf/B-Raf V600E with IC50 of 3-60 nM, and exhibits potent inhibition on VEGFR2 phosphorylation with EC50 of 30 nM. Phase 2.		Apoptosis , Raf , VEGFR , Autophagy
T1886	TAK-632		Raf , FGFR , PDGFR , Aurora Kinase
	TAK-632 is a potent pan-Raf inhibitor.		Raf , FGFR , PDGFR , Aurora Kinase
T6487	Encorafenib	LGX818	Raf
	Encorafenib (LGX818) is an orally available mutated BRaf V600E inhibitor(IC50=0.3 nM) with potential antineoplastic activity.		Raf
T1953	L-779450	L 779450	Raf , Autophagy
	L-779450, an effective, ATP-competitive Raf kinase inhibitor (IC50: 10 nM) , displays > 7, > 30 and > 70-fold selectivity over p38α, GSK3β and Lck respectively.		Raf , Autophagy
T11224	Rineterkib	ERK-IN-1	ERK , Raf
			ERK , Raf
T24437	MCP110	MCP-110,MCP 110	Raf , Ras
	MCP110 is an inhibitor of the interaction of Ras with Raf-1 and can be used in studies about the treatment of human tumors.		Raf , Ras
T1851	ZM 336372	Zinc00581684	Apoptosis , Raf
	ZM 336372 is a potent and selective c-Raf inhibitor.		Apoptosis , Raf
T9693	TBAP-001		Raf
	TBAP-001 is a RAF kinase inhibitor, with an IC50 of 62 nM in BRAF V600E kinase assay and an IC50 of 18 nM in Cell-Based Phosho-ERK Assay.		Raf
T4301	AD80		Raf , c-RET , Src , S6 Kinase
	AD80, a multikinase inhibitor, inhibits RET, RAF, SRCand S6K, with greatly reduced mTOR activity.		Raf , c-RET , Src , S6 Kinase
T5634	Belvarafenib		Raf
	Belvarafenib is a potent and pan RAF inhibitor with antineoplastic activity. The IC50 values of Belvarafenib are 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively.		Raf
T1903	Dabrafenib	GSK2118436A,GSK2118436	Raf
	Dabrafenib (GSK2118436A) is a Raf inhibitor that inhibits C-Raf and B-RafV600E (IC50=5/0.6 nM) and is ATP-competitive. Dabrafenib exhibits antitumor activity for the treatment of B-RafV600E-mutated melanoma.		Raf
T6949	PLX7904	PB04	Raf
	PLX7904 (PB04), also known as PB04, is a potent and selective paradox-breaker RAF inhibitor. It is able to efficiently inhibit activation of ERK1/2 in mutant BRAF melanoma cells but does not hyperactivate ERK1/2 in mutan...		Raf
T6320	GDC-0879	GDC 0879,AR-00341677,GDC0879	Raf
	GDC-0879 (AR-00341677) is a novel, potent and selective B-Raf inhibitor with IC50 of 0.13 nM with activity against c-Raf as well.		Raf
T11898	LXH254		Raf
	LXH254 is a potent C-Raf and B-Raf inhibitor.		Raf
T6882	LY3009120	DP-4978	Raf , Autophagy
	LY3009120 (DP-4978) is a potent pan-Raf inhibitor with IC50 of 44 nM, 31-47 nM, and 42 nM for A-raf, B-Raf, and C-Raf in A375 cells, respectively. Phase 1.		Raf , Autophagy
T41003	KG5		Raf , FLT , PDGFR , c-Kit
	KG5 is a dual allosteric inhibitor of PDGFRβ and B-Raf with a Kd of 520 nM and 300 nM for PDGFRβ and PDGFRα. KG5 inhibits FLT3, KIT, and c-Raf with anticancer and antiangiogenic activities.		Raf , FLT , PDGFR , c-Kit
T6277	Doramapimod	BIRB 796	Raf , p38 MAPK , Autophagy
	Doramapimod (BIRB 796) is a highly potent inhibitor of p38 MAPK (Kd: 0.1 nM), but weakly inhibits c-RAF, Fyn, Lck, ERK-1, SYK, IKK2, and ZAP-70.		Raf , p38 MAPK , Autophagy
T22272	Lifirafenib	BGB-283,Beigene-283	EGFR , Raf
	Lifirafenib (Beigene-283) is a potent inhibitor of RAF family kinases and EGFR in biochemical assays with IC50 of 23, 29 and 495 nM for the recombinant BRAFV600E kinase domain, EGFR and EGFR T790M/L858R mutant respective...		EGFR , Raf
T8745	PROTAC BRAF-V600E degrader-1	Compound 23	Raf
	PROTAC BRAF-V600E degrader-1 (Compound 23) selectively induces degradation of BRAF-V600E but not wildtype BRAF.		Raf
T2070	Agerafenib	RXDX-105,CEP 32496,CEP-32496,CEP32496	Raf , c-RET , Bcr-Abl , PDGFR , Src , c-Kit
	Agerafenib (CEP32496) is a highly potent inhibitor of BRAF.		Raf , c-RET , Bcr-Abl , PDGFR , Src , c-Kit
T22436	Takeda-6d		VEGFR
	Takeda-6d, a novel, potent DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor, inhibits B-RAF and VEGFR2 with IC50 of 7.0nM and 2.2nM.		VEGFR
T6895	TAK-580	MLN2480,BIIB-024	Raf
	TAK-580 (MLN2480) is an oral, selective pan-Raf kinase inhibitor in Clinicalal trials.		Raf
T6971	Ro 5126766	CH5126766,Avutometinib,VS-6766,RO5126766	Raf , MEK
	RO5126766 (CH5126766) is a dual RAF/MEK inhibitor with IC50 of 8.2 nM, 19 nM, 56 nM, and 160 nM for BRAF V600E, BRAF, CRAF, and MEK1, respectively. Phase 1.		Raf , MEK
T0093L	Sorafenib	Bay 43-9006	Apoptosis , Raf , VEGFR , FLT , Ferroptosis , PDGFR , c-Kit , Autophagy
	Sorafenib (Bay 43-9006) is a multikinase inhibitor that inhibits Raf-1, B-Raf, VEGFR2, VEGFR3, VEGFR4, PDGFRβ, FLT3, c-Kit, and others (IC50=6/22/90/15/20/20/57/58 nM) with oral activity. Sorafenib has antitumor activity...
T1792L	Regorafenib monohydrate		Raf , VEGFR , c-RET , PDGFR , c-Kit , Autophagy
	Regorafenib Monohydrate is a novel oral multikinase inhibitor with IC50 values of 13, 4.2, 46, 22, 7, 1.5, 2.5, 28, 19 nM for VEGFR1, murine VEGFR2, murine VEGFR3, PDGFR-β, KIT, RET, RAF-1, B-RAF and B-RAF(V600E) respect...		Raf , VEGFR , c-RET , PDGFR , c-Kit , Autophagy
T8402	Regorafenib Hydrochloride	BAY73-4506 hydrochloride	Raf , VEGFR , c-RET , PDGFR , Autophagy
	Regorafenib Hydrochloride (BAY73-4506 hydrochloride) is a new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity		Raf , VEGFR , c-RET , PDGFR , Autophagy
T2382	Vemurafenib	RO5185426,RG7204,PLX4032	Raf , MAPK , ACK , Src , Autophagy
	Vemurafenib (RG7204) is a B-RAF inhibitor that inhibits RAFV600E and c-RAF-1 (IC50=31/48 nM) selectively and potently. Vemurafenib exhibits antitumor activity and is used for the treatment of BRAF V600E mutation-positive...		Raf , MAPK , ACK , Src , Autophagy
T0093	Sorafenib tosylate	Bay 43-9006	Apoptosis , Raf , VEGFR , FLT , Ferroptosis , PDGFR , c-Kit , Autophagy
	Sorafenib tosylate (Bay 43-9006) is a potent multikinase inhibitor (IC50s: 6/20/22 nM for Raf-1/VEGFR-3/B-Raf).
T6525	GW 5074	GW5074,Raf1 Kinase Inhibitor I	Apoptosis , Raf
	GW 5074 (Raf1 Kinase Inhibitor I)(IC50=9 nM) is an effective and specific c-Raf inhibitor. It has no effect on the activities of JNK1/2/3, MEK1, MKK6/7, CDK1/2, c-Src, p38 MAP, VEGFR2 or c-Fms.		Apoptosis , Raf
T8474	Dabrafenib Mesylate	GSK 2118436B,GSK2118436 Mesylate	Raf
	Dabrafenib Mesylate (GSK2118436 Mesylate) is a B-Raf inhibitor(IC50s of 0.6 and 5.0 nM for RafV600E and c-Raf, respectively).		Raf
T1792	Regorafenib	BAY 73-4506,Fluoro-Sorafenib	Raf , VEGFR , c-RET , PDGFR , c-Kit , Autophagy
	Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor that inhibits RET, C-RAF, VEGFR2, c-Kit, VEGFR1, and PDGFRβ and is orally active. Regorafenib has antitumor and anti-angiogenic activity.		Raf , VEGFR , c-RET , PDGFR , c-Kit , Autophagy
T38511	AWL-II-38.3		Ephrin Receptor
	AWL-II-38.3 is a highly effective inhibitor of EphA3, a receptor for ephrin-A. It demonstrates potent kinase inhibitory activity against EphA3 and does not show significant cellular activity against Src-family kinases or...		Ephrin Receptor
T68170	Xl-281
	XL-281 is a potent, selective, orally active inhibitor of wild-type and mutant RAF kinases with anti-tumor activity in multiple xenograft models; demonstrates biological activity by modulation of the RAF pathway in tumor...
T71736	AMG-628, (R)-
	AMG-628, (R)- is the R isomer of AMG-628 --- a potent, ATP-competitive inhibitor of Raf kinases. AMG-628 displays selectivity for Raf kinases and inhibits activation of tyrosine protein kinases such as VEGFR2, Lyn, Flt1 ...
T68523	AMG-628, (S)-
	AMG-628, (S)-, is the S isomer of AMG-628 --- a potent, ATP-competitive inhibitor of Raf kinases. AMG-628 displays selectivity for Raf kinases and inhibits activation of tyrosine protein kinases such as VEGFR2, Lyn, Flt1...
T25350	DPQZ
	DPQZ is an anti-tubulin compound acting by inducing cell apoptosis in human oral cancer cells through Ras/Raf inhibition and MAP kinases activation.
T28510	REDX05358	REDX 05358,REDX-05358
	REDX05358 is a highly selective and potent pan RAF inhibitor with a potential therapeutic for BRAF and RAS mutant tumors. REDX05358 has improved therapeutic potential and predicted safety profile. REDX05358 demonstrates ...

Compounds

RAF709

Synonym: B-Raf inhibitor 1

Target: Raf

Raf inhibitor 1 dihydrochloride

T4167

Synonym: B-Raf inhibitor 1 dihydrochloride

Synonym: CID-25014542,CID 25014542,CID25014542

Target: c-Fms, Raf, p38 MAPK, Autophagy

AZ 628

T6318

Synonym:

Target: Apoptosis, Raf

RAF265

T6296

Synonym: CHIR-265

Target: Apoptosis, Raf, VEGFR, Autophagy

TAK-632

T1886

Synonym:

Target: Raf, FGFR, PDGFR, Aurora Kinase

Target: Raf, Autophagy

Synonym: MCP-110,MCP 110

Target: Raf, Ras

ZM 336372

T1851

Synonym: Zinc00581684

Target: Apoptosis, Raf

Target: Raf, c-RET, Src, S6 Kinase

Synonym: GSK2118436A,GSK2118436

Synonym: GDC 0879,AR-00341677,GDC0879

Target: Raf, Autophagy

KG5

T41003

Synonym:

Target: Raf, FLT, PDGFR, c-Kit

Doramapimod

T6277

Synonym: BIRB 796

Target: Raf, p38 MAPK, Autophagy

Lifirafenib

T22272

Synonym: BGB-283,Beigene-283

Target: EGFR, Raf

PROTAC BRAF-V600E degrader-1

Synonym: RXDX-105,CEP 32496,CEP-32496,CEP32496

Target: Raf, c-RET, Bcr-Abl, PDGFR, Src, c-Kit

Synonym: MLN2480,BIIB-024

Target: Raf

Ro 5126766

T6971

Synonym: CH5126766,Avutometinib,VS-6766,RO5126766

Target: Apoptosis, Raf, VEGFR, FLT, Ferroptosis, PDGFR, c-Kit, Autophagy

Regorafenib monohydrate

T1792L

Synonym:

Target: Raf, VEGFR, c-RET, PDGFR, c-Kit, Autophagy

Regorafenib Hydrochloride

T8402

Synonym: BAY73-4506 hydrochloride

Target: Raf, VEGFR, c-RET, PDGFR, Autophagy

Vemurafenib

T2382

Synonym: RO5185426,RG7204,PLX4032

Target: Raf, MAPK, ACK, Src, Autophagy

Sorafenib tosylate

T0093

Synonym: Bay 43-9006

Target: Apoptosis, Raf, VEGFR, FLT, Ferroptosis, PDGFR, c-Kit, Autophagy

GW 5074

T6525

Synonym: GW5074,Raf1 Kinase Inhibitor I

Target: Apoptosis, Raf

Dabrafenib Mesylate

T8474

Synonym: GSK 2118436B,GSK2118436 Mesylate

Target: Raf

Regorafenib

T1792

Synonym: BAY 73-4506,Fluoro-Sorafenib

Target: Raf, VEGFR, c-RET, PDGFR, c-Kit, Autophagy

AWL-II-38.3

T38511

Synonym:

Target: Ephrin Receptor

Synonym: REDX 05358,REDX-05358

Target:

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-05095	RAF1 Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	RAF1 gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds direct...
TMPY-04411	YES1 Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	Proto-oncogene tyrosine-protein kinase Yes, also known as Proto-oncogene c-Yes, p61-Yes and YES1, is a cytoplasm protein that belongs to the protein kinase superfamily, Tyr protein kinase family and SRC subfamily. YES1 /...
TMPY-03534	CDC37 Protein, Mouse, Recombinant (His & GST)	Mouse	Baculovirus-Insect Cells
	CDC37 is a protein that is expressed in proliferative zones during embryonic development and in adult tissues, consistent with a positive role in proliferation and is required for cell division in budding yeast. CDC37 is...
TMPY-01715	CDC37 Protein, Human, Recombinant (GST)	Human	Baculovirus-Insect Cells
	CDC37 is a protein that is expressed in proliferative zones during embryonic development and in adult tissues, consistent with a positive role in proliferation and is required for cell division in budding yeast. CDC37 is...
TMPY-03558	CDC37 Protein, Mouse, Recombinant	Mouse	Baculovirus-Insect Cells
	CDC37 is a protein that is expressed in proliferative zones during embryonic development and in adult tissues, consistent with a positive role in proliferation and is required for cell division in budding yeast. CDC37 is...

RAF1 Protein, Human, Recombinant (His & GST)

TMPY-05095

Species: Human

Expression System: Baculovirus-Insect Cells

YES1 Protein, Human, Recombinant (His & GST)

TMPY-04411

Species: Human

Expression System: Baculovirus-Insect Cells

CDC37 Protein, Mouse, Recombinant (His & GST)

TMPY-03534

Species: Mouse

Expression System: Baculovirus-Insect Cells

CDC37 Protein, Human, Recombinant (GST)

TMPY-01715

Species: Human

Expression System: Baculovirus-Insect Cells

CDC37 Protein, Mouse, Recombinant

TMPY-03558

Species: Mouse

Expression System: Baculovirus-Insect Cells

カタログ番号	製品名
L1610	FDA-Approved Kinase Inhibitor Library	263 compounds
	A unique collection of 263 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.
L1600	Kinase Inhibitor Library	2700 compounds
	A unique collection of 2700 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;

ライブラリー

FDA-Approved Kinase Inhibitor Library

L1610

Compounds: 263

Kinase Inhibitor Library

L1600

Compounds: 2700